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TB-500
Also known as: Thymosin Beta-4, Tβ4
A synthetic version of thymosin beta-4, a naturally occurring peptide involved in cell migration, tissue repair, and inflammation regulation.
Quick Facts
- Sequence
- LKKTETQ (active fragment)
- Molecular Weight
- 4963 Da
Overview
TB-500 is a synthetic peptide based on the active region of thymosin beta-4 (Tβ4), a 43-amino acid protein naturally produced by the thymus gland. Thymosin beta-4 is one of the most abundant intracellular proteins and plays a critical role in actin sequestration, cell motility, and wound healing processes.
Research has explored its potential in tissue repair, cardiovascular protection, and anti-inflammatory applications, primarily in animal models and cell culture studies.
Mechanism of Action
TB-500 acts primarily through its interaction with actin, a key cytoskeletal protein. By sequestering G-actin monomers, it promotes cell migration and proliferation. It also upregulates expression of actin in cells, facilitating wound healing processes. Research suggests it may reduce inflammation through downregulation of inflammatory cytokines and promote angiogenesis.
Biological Pathways
Research Findings
Animal studies have demonstrated potential benefits in cardiac repair after myocardial infarction, corneal wound healing, dermal wound repair, and reduction of inflammatory markers. Equine studies have shown some promise in tendon and ligament repair. Human clinical data is very limited, with a few early-phase trials in cardiac patients.
Risks & Safety Concerns
Limited human safety data. Potential concerns include effects on tumor growth due to pro-angiogenic and cell-proliferative properties. Quality and purity of research-grade products varies. Not recommended for individuals with active cancers or those at high risk.
Regulatory & Legal Status
TB-500 is not approved for human use by the FDA. It is available as a research peptide. Thymosin beta-4 has been studied in some clinical trials. Listed on WADA prohibited list.
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