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Ipamorelin
Also known as: NNC 26-0161
A selective growth hormone secretagogue peptide studied for its ability to stimulate growth hormone release with fewer side effects than other GH secretagogues.
Quick Facts
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Molecular Weight
- 711.85 Da
Overview
Ipamorelin is a synthetic pentapeptide that acts as a selective growth hormone secretagogue receptor (GHSR) agonist. It was developed to stimulate growth hormone release while minimizing effects on cortisol and prolactin, distinguishing it from other GH secretagogues like GHRP-6.
Research has explored its potential in growth hormone deficiency, bone health, and metabolic applications.
Mechanism of Action
Ipamorelin selectively binds to the ghrelin/growth hormone secretagogue receptor (GHSR) in the pituitary gland, stimulating growth hormone release in a dose-dependent manner. Unlike other GH secretagogues, it does not significantly affect ACTH, cortisol, or prolactin levels, suggesting higher selectivity for GH pathways.
Biological Pathways
Research Findings
Phase II clinical trials have been conducted for post-surgical ileus recovery. Animal studies demonstrate GH release without cortisol/prolactin elevation. Some studies suggest beneficial effects on bone mineral density. Research on metabolic effects is ongoing. No peptide has been approved as a standalone GH secretagogue for general use.
Risks & Safety Concerns
Potential risks include disruption of natural GH pulsatility, headache, lightheadedness, and water retention. Long-term safety of chronic GH elevation is not established in this context. Concerns about effects on glucose metabolism and insulin sensitivity. Quality of research-grade products varies.
Regulatory & Legal Status
Not approved by FDA for any indication. Available as a research peptide. Sometimes prescribed off-label by anti-aging clinics. Listed on WADA prohibited list.
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