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Epitalon
Also known as: Epithalon, Epithalone, AEDG Peptide
A synthetic tetrapeptide studied for its potential effects on telomerase activation and melatonin regulation.
Quick Facts
- Sequence
- Ala-Glu-Asp-Gly
- Molecular Weight
- 390.35 Da
Overview
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on the natural peptide epithalamin, which is derived from the pineal gland. Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, it has been studied primarily in Russian research for its potential anti-aging properties.
Research interest centers on its reported ability to activate telomerase and regulate melatonin production.
Mechanism of Action
Epitalon is hypothesized to activate telomerase, the enzyme that maintains telomere length at chromosome ends. It may also stimulate melatonin production from the pineal gland and regulate the neuroendocrine system. Some research suggests it influences gene expression related to aging and antioxidant defense systems.
Biological Pathways
Research Findings
In vitro studies have shown telomerase activation in human somatic cells. Animal studies (primarily in rodents) report increased lifespan, restored melatonin rhythms, and improved immune function. Human studies are limited to small Russian clinical observations reporting improvements in melatonin production and some biomarkers. No large-scale international RCTs exist.
Risks & Safety Concerns
Very limited safety data in humans. Telomerase activation raises theoretical concerns about cancer risk, as telomerase is upregulated in many cancers. Quality of research peptide products varies. Long-term effects completely unknown.
Regulatory & Legal Status
Not approved for human use by major regulatory agencies. Available as a research peptide. No specific regulatory restrictions in most jurisdictions beyond standard research chemical regulations.
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