This information is for educational purposes only and does not constitute medical advice.
BPC-157
Also known as: Body Protection Compound-157, Bepecin
A pentadecapeptide derived from human gastric juice, studied for its potential role in tissue repair and gastrointestinal protection.
Quick Facts
- Sequence
- Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular Weight
- 1419.53 Da
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids. It is derived from a protein found in human gastric juice. Research has primarily focused on its effects in animal models, examining its potential roles in wound healing, gastrointestinal tract protection, and tissue repair mechanisms.
The peptide has been the subject of numerous preclinical studies investigating its interaction with various biological pathways including the nitric oxide system, growth factor expression, and angiogenesis. While animal study results have shown promise in several areas, human clinical data remains extremely limited.
Mechanism of Action
BPC-157 is hypothesized to interact with the nitric oxide (NO) system and may influence several growth factor pathways. In vitro and animal studies suggest it may promote angiogenesis (formation of new blood vessels) and upregulate growth hormone receptor expression. It appears to interact with the dopamine system, GABAergic system, and opioid systems in animal models. The exact molecular mechanisms remain under active investigation.
Biological Pathways
Research Findings
Animal studies have reported effects including acceleration of wound healing in various tissue types (tendon, muscle, bone, skin), gastroprotective effects against various ulcer models, potential neuroprotective properties, and interactions with the cardiovascular system. A limited number of small-scale human studies have examined its use in inflammatory bowel disease. No large-scale randomized controlled trials have been completed to date.
Risks & Safety Concerns
As a research peptide without full clinical trials, the long-term safety profile in humans is not established. Potential risks include unknown drug interactions, effects on tumor growth pathways (due to angiogenic properties), and lack of standardized dosing data. Quality control of research-grade peptides varies significantly between sources.
Regulatory & Legal Status
BPC-157 is not approved by the FDA for any medical use. It is available as a research chemical in many jurisdictions. It is not scheduled as a controlled substance in most countries. WADA has included it on its prohibited list for athletes.
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